Broad-Spectrum Herbal Formula
(Anti-inflammatory, Antioxidant and TNF-inhibiting)
Radical Oxygen Species (ROS), elevated TNF-alpha and inflammation are known to play a significant role in many cases of infertility in both men and women.
Radical Oxygen Species (ROS) and Infertility
Radical Oxygen Species (ROS, also called “free radicals”) include the hydroxyl radical, hydrogen peroxide, lipid peroxide, hypochlorite, chloramines, superoxide anion, peroxyl radical to name just a few. Inflammation is a primary cause of increased ROS.
In women, Radical Oxygen Species are detrimental to both natural and assisted fertility.1-8 ROS is also associated with polycystic ovarian disease, endometriosis, spontaneous abortions, preeclampsia, hydatidiform mole, embryopathies, preterm labor, and intrauterine growth retardation.2-3
In men, Radical Oxygen Species have been shown to decrease sperm motility and concentration and is associated with male infertility of unknown cause.9-32 ROS in males also damages DNA and should therefore be corrected even when assisted pregnancy is planned.31,36,40 The effect of ROS on male fertility is so well-established that many fertility specialists consider routinely testing for ROS in sub-fertile men.
Tumor Necrosis Factor-alpha (TNF-α) and Infertility
Tumor Necrosis Factor-alpha (TNF-a) is an inflammatory cytokine that stimulates free radical production by mitochondria. Don’t let the term “tumor” alarm you; everyone has TNF-α in their body. Excessive amounts of TNF-α impair fertility.
In women, high TNF-α suppresses ovarian function, increases Natural Killer cells (NK cells) and is associated with infertility. High TNF-α is also associated with recurrent spontaneous abortion.
In men, high TNF-α is associated with decreased sperm count and motility.20
Broad-Spectrum Herbal Formula
Maxi Flavone is a broad-spectrum herbal antioxidant formula that affords protection from multiple ROS species, lowers TNF-alpha and is anti-inflammatory. Flavonoid-containing herbs have a synergistic effect when used in combination.41,71
Maxi Flavone supplies therapeutic doses of the most well-studied flavonoid herbs including:
I.) Pycnogenol (Pinus maritima) antioxidant and antiinflammatory effects. Please see the extensive reference list elsewhere on this website:
Grape Seed Extract and Pycnogenol
II.) Red Grape Seed (Vitus vinifera) with seeds, skin and stems which therefore contains Resveretrol. Both have potent antioxidant and anti-inflammatory effects. Please see the extensive reference list on my website: /grapeseed__trashed/ . Resveretrol also suppresses TNF-α.72 Please see the extensive reference list elsewhere on this website: Grape Seed Extract
III.) Bilberry (Vaccinium myrtillus), the most potent of the edible berries (39), has significant antioxidant and anti-inflammatory properties 41-43,73-7. Bilberry inhibits TNF-α43 , lipid peroxidation73-74 and is an active radical scavenger of H2O242,76, superoxide and peroxynitrite.41
IV.) Green Tea (Camillia sinesis) is an antioxidant that suppresses TNF-α.44-48 It has been shown to cause regression of endometriosis in animal models.49-50
V.) Ginkgo (Ginkgo biloba) is an antioxidant that has TNF-α suppressing properties.51-57 Ginkgo raises the radical-scavenging enzymes glutathione, SOD and catalase.51-52 It has also been shown to relieve symptoms of congestive PMS.56
VI.) Milk Thistle (Silybum marianum) is an antioxidant and antiinflammatory59-63 that significantly inhibits TNF-α. 58-61,63
It has been shown to modulate immune response in vivo.60
VII.) Citrus Bioflavonoids (with hesperidin, narginen and other flavonoids) have antioxidant64-67,69, antiinflammatory58,60,64,66, and TNF-a inhibiting properties.64
Why Dr. Myatt Recommends Maxi Flavone™
Maxi Flavone is a state-of-the-art formulation of flavonoid-containing herbs with synergistic effects specific to fertility enhancement. Only full-spectrum extracts, not isolated flavonoids are included, thus preserving the synergistic activity of all naturally-occurring phytonutrient compounds.
Maxi Flavone contains optimal doses of the flavonoid herbs which quench Radical Oxygen Species (ROS), lower TNF-α and NK cell activity (only when excessive) and decrease excess inflammation.
In addition to the beneficial effect on fertility, these herbs also have numerous beneficial effects on overall health. Maxi Flavone™ is a potent formula providing support for immune function, circulatory health, liver detoxification mechanisms, and antioxidant pathways.
Suggested Dose for Fertility:
Women: 1 capsule per day with a meal.
Men: 1 capsule, 2 times per day with meals.
NOTE: Two capsules of Maxi Flavone™ is equivalent to 10 to 12 tablets or capsules of individual extracts taken separately, resulting in significant cost savings.
Due to strong interest in this formula we may occasionally become backordered, with shipping delayed by up to a week.
Because of this we recommend that our Maxi Flavone customers consider ordering two bottles, re-order when they have completed the first bottle and never worry about running out of this important flavonoid / antioxidant / TNF-inhibiting formula.
For our fertility patients and customers, Dr. Myatt recommends that this formula be continued through conception and for the duration of pregnancy.
Product # N308 (60 Caps) $46.95
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Supplement Facts Serving Size 1 Capsule (60 Caps per bottle)
Amount Per Capsule % Daily Value
Pycnogenol®** Pine Bark (Pinus maritima) dried extract 5 mg *
Red Grape (Vitis vinifera) seeds, skin, and stems, dried extract with resveratrol 100 mg *
Bilberry (Vaccinum myrtillus) fruit, dried extract, min. 25% anthocyanosides 60 mg *
Green Tea (Camellia sinensis) leaf, dried extract, min. 50% catechins (polyphenols) 180 mg *
Ginkgo (Ginkgo Biloba) leaf, dried extract, min. 24% ginkgo flavone glycosides and 6% terpene lactones 40 mg *
Milk Thistle (Silybum marianum) fruit, dried extract, min. 80% silymarin 100 mg *
Citrus Bioflavonoid Complex, min. 50% bioflavonoids 125 mg *
* Daily value not established
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